Publication Highlights

Ahnak scaffolds p11/Anxa2 complex and L-type voltage-gated calcium channel and modulates depressive behavior.

Jin J, Bhatti DL, Lee KW, Medrihan L, Cheng J, Wei J, Zhong P, Yan Z, Kooiker C, Song C, Ahn JH, Obermair GL, Lee A, Gresack J, Greengard P, Kim Y. Molecular Psychiatry. 2020 May. doi: 10.1038/s41380-019-0371-y

WAVE1 in neurons expressing the D1 dopamine receptor regulates cellular and behavioral actions of cocaine.

Ceglia I, Lee KW, Cahill ME, Graves SM, Dietz D, Surmeier DJ, Nestler EJ, Nairn AC, Greengard P, Kim Y. Proc Natl Acad Sci. 2017 Feb. doi: 10.1073/pnas.1621185114

Alteration by p11 of mGluR5 localization regulates depression-like behaviors.

Lee KW, Westin L, Kim J, Chang JC, Oh YS, Amreen B, Gresack J, Flajolet M, Kim D, Aperia A, Kim Y, Greengard, P. Molecular Psychiatry. 2015 Dec. doi: 10.1038/mp.2015.132

APP intracellular domain-WAVE1 pathway reduces amyloid-B production.

Ceglia I, Reitz C, Gresack J, Ahn JH, Bustos V, Bleck M, Zhang X, Martin G, Simon SM, Nairn AC, Greengard P, Kim Y. Nature Medicine. 2015 Sep. doi: 10.1038/nm.3924

p11 and its role in depression and therapeutic responses to antidepressants.

Svenningsson P, Kim Y, Warner-Schmidt J, Oh YS, Greengard, P. Nat Rev Neurosci. 2013 Oct. doi: 10.1038/nrn3564

SMARCA3, a chromatin-remodeling factor, is required for p11-dependent antidepressant action.

Oh YS, Gao P, Lee KW, Ceglia I, Seo JS, Zhang X, Ahn JH, Chait BT, Patel DJ, Kim Y, Greegard P. Cell. 2013 Feb. doi:10.1016/j.cell.2013.01.014

Signaling pathways controlling the phosphorylation state of WAVE1, a regulator of actin polymerization

Ceglia I, Kim Y, Nairn AC, Greengard, P. Journal of Neurochemistry. 2010 June. doi: 10.1111/j.1471-4159.2010.06743.x

Methylphenidate-induced dendritic spine formation and DeltaFosB expression in nucleus accumbens.

Kim Y, Teylan MA, Baron M, Sands A, Nairn AC, Greengard, P. Proc Natl Acad Sci. 2009 Feb. doi: 10.1073/pnas.0813179106

WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines.

Sung JY, Engmann O, Teylan MA, Nairn AC, Greengard P, Kim Y. Proc Natl Acad Sci. 2008 Feb. doi: 10.1073/pnas.0712180105

Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology.

Kim Y, Sung JY, Ceglia I, Lee KW, Ahn JH, Halford JM, Kim AM, Kwak SP, Park JB, Ho Ryu S, Schenck A, Bardoni B, Scott JD, Nairn AC, Greengard P. Nature. 2006 Aug. doi: 10.1038/nature04976

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