Ahnak scaffolds p11/Anxa2 complex and L-type voltage-gated calcium channel and modulates depressive behavior.
Jin J, Bhatti DL, Lee KW, Medrihan L, Cheng J, Wei J, Zhong P, Yan Z, Kooiker C, Song C, Ahn JH, Obermair GL, Lee A, Gresack J, Greengard P, Kim Y. Molecular Psychiatry. 2020 May. doi: 10.1038/s41380-019-0371-y
WAVE1 in neurons expressing the D1 dopamine receptor regulates cellular and behavioral actions of cocaine.
Alteration by p11 of mGluR5 localization regulates depression-like behaviors.
APP intracellular domain-WAVE1 pathway reduces amyloid-B production.
p11 and its role in depression and therapeutic responses to antidepressants.
SMARCA3, a chromatin-remodeling factor, is required for p11-dependent antidepressant action.
Signaling pathways controlling the phosphorylation state of WAVE1, a regulator of actin polymerization
Methylphenidate-induced dendritic spine formation and DeltaFosB expression in nucleus accumbens.
WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines.
Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology.